Safety and efficacy of pimecrolimus in atopic dermatitis: a 5-year randomized trial.

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Safety and efficacy of tacrolimus ointment versus pimecrolimus cream in the treatment of patients with atopic dermatitis previously treated with corticosteroids.

Adult and pediatric patients (n = 347) with atopic dermatitis enrolled in three multicenter, randomized, 6-week studies who had previously used steroids were analyzed to examine the null hypothesis that improvement in atopic dermatitis initiated after prior treatment with steroids eliminates any subsequent treatment differences between tacrolimus ointment and pimecrolimus cream. Of these patien...

Functional interpretation of metabolomics data as a new method for predicting long-term side effects: treatment of atopic dermatitis in infants

Topical steroids are used for the treatment of primary atopic dermatitis (AD); however, their associated risk of serious complications is great due to the presence of vulnerable lesions in young children with AD. Topical calcineurin inhibitors (TCIs) are steroid-free, anti-inflammatory agents used for topical AD therapy. However, their use is prohibited in infants <2 years of age because of the...

Clinical inquiries. What is the role of tacrolimus and pimecrolimus in atopic dermatitis?

■ Evidence summary A recent meta-analysis included 25 randomized controlled trials involving tacrolimus and pimecrolimus. This review included trials of tacrolimus and pimecrolimus in comparison with placebo, topical corticosteroids of varying strengths, and each other. They reported on both safety and efficacy. Fifteen vehiclecontrolled trials of pimecrolimus and tacrolimus were reviewed. Both...

Efficacy and tolerability of topical pimecrolimus and tacrolimus in the treatment of atopic dermatitis: meta-analysis of randomised controlled trials.

OBJECTIVE To determine the efficacy and tolerability of topical pimecrolimus and tacrolimus compared with other treatments for atopic dermatitis. DESIGN Systematic review and meta-analysis. DATA SOURCES Electronic searches of the Cochrane Library, Medline, and Embase. STUDY SELECTION Randomised controlled trials of topical pimecrolimus or tacrolimus reporting efficacy outcomes or tolerabi...